منابع مشابه
Regulation of Oxidative Phosphorylation
Introduction Thyroid hormones (TI Is) affect cellular metabolism via two different pathways. The first one is the socalled nuclear, long-term effect: there the TI I binds to a nuclear receptor and regulates the transcription o f multiple cellular proteins f 11. The other pathway, the short-term extranuclear pathway, is less w d l defined and could in principle be similar to other short-term sig...
متن کاملBarbiturates and oxidative phosphorylation.
It has been claimed that barbiturates uncouple oxidative phosphorylations (Brody & Bain, 1954; Brody, 1955). These authors have demonstrated that during the oxidation of pyruvate by liver and brain mitochondria, phosphate uptake was lowered proportionately more than oxygen uptake. Support for the uncoupling theory was derived from certain similarities between the barbiturates and 2:4dinitrophen...
متن کاملOxidative phosphorylation revisited.
The fundamentals of oxidative phosphorylation and photophosphorylation are revisited. New experimental data on the involvement of succinate and malate anions respectively in oxidative phosphorylation and photophosphorylation are presented. These new data offer a novel molecular mechanistic explanation for the energy coupling and ATP synthesis carried out in mitochondria and chloroplast thylakoi...
متن کاملUncouplers of oxidative phosphorylation.
Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase (H(+)-ATPase). Miscellaneous compounds are known to be uncouplers, but weakly acidic uncouplers are representative because they show very potent activities. The most poten...
متن کاملUncouplers of Oxidative Phosphorylation
was proportional to the acidity of the imidazole -NH group. Tetrachloro-2trifluoromethylbenzimidazole was the most active (50% uncoupling of oxidative phosphorylation at 7-9 x 10-8M, pK5.04). Nitro-substituted analogues were less active than predicted from pK considerations or from partition-coefficient measurements. 3. Introduction of an -NH2 or -CO2H substituent caused a loss of uncoupling ac...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1953
ISSN: 0306-3283
DOI: 10.1042/bj0540107